After the drying of its neighboring lake, Lake Lapsista, Lake Pamvotis, the renowned Lake of Ioannina, has suffered accelerating degradation. Presently, its natural function remains disrupted and pollution is evident. In recent years, development has created the conditions for the progressive destruction of its ecosystem. This study is concerned with the intertwined history of nature and human impacts, made manifest in the landscape of the basin of Ioannina.